I was too old to grow up with Pinky and the Brain, but what I've seen of it has quite impressed me. It's well animated, well written, and appreciable by adults as well as kids.
They have a running gag where Brain asks Pinky, "Are you pondering what I'm pondering?" Pinky replies, "I think so, Brain, but..." and delivers an absolute non sequitur.
Isn't it wonderful that somebody put them all together?