There's a book coming out today from Randy Pausch called The Last Lecture. It's a tradition at some colleges and universities to have professors give a lecture and imagine it to be their last. In Pausch's case, when he was asked to do so, that wasn't such a hypothetical - he'd just been diagnosed with terminal cancer.
The resultant talk has become semilegendary. YouTube has a 75-minute version here, but Oprah used her Oprah powers and got him to squash it down to ten minutes. The points, and they're powerful, wonderful points, come across just fine.
Please don't skip this just because it's an extended clip. Take the time. You'll not be sorry.